Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 5/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.37 |
| ▸ | CDC42BPB | Q9Y5S2 | 2/20 | 0.37 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 2/20 | 0.32 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.32 |
| ▸ | CCNC | P24863 | 1/20 | 0.32 |
| ▸ | SYK | P43405 | 2/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.31 |
| ▸ | PLK4 | O00444 | 1/20 | 0.31 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.31 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.31 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.31 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.31 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PRKCG | P05129 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2878522 | 0.85 | JAK2 (0.38) | JAK2ROCK2ROCK1CDK8CDC42BPA | |
| SCHEMBL2877013 | 0.84 | PRKCI (0.40) | JAK2ROCK2ROCK1CDK8CDC42BPA | |
| SCHEMBL2876903 | 0.82 | ALDH1A1 (0.38) | CDC7KDRAURKBAKT3 | |
| SCHEMBL2876532 | 0.80 | ADORA2A (0.47) | — | |
| SCHEMBL2874794 | 0.80 | JAK2 (0.40) | JAK2ROCK2ROCK1CDC42BPBPTPN11 | |
| SCHEMBL2878514 | 0.76 | AKT1 (0.48) | ROCK2ROCK1CDC42BPAMAPK13DYRK3 | |
| SCHEMBL2876171 | 0.76 | CDC42BPB (0.41) | JAK2ROCK2ROCK1CDC42BPBCDC42BPA | |
| SCHEMBL2874152 | 0.76 | NPC1 (0.46) | ROCK2ROCK1 | |
| SCHEMBL2873639 | 0.75 | AKT1 (0.45) | ROCK2ROCK1SYKPIM1AKT1 | |
| Hydrochloric Acid SCHEMBL2878733 | 0.74 | AKT1 (0.45) | ROCK2ROCK1SYKPIM1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |