Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC42BPB | Q9Y5S2 | 19/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 18/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 17/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | CDC42BPA | Q5VT25 | 4/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2876524 | 0.87 | ROCK1 (0.36) | CDC42BPBROCK1ROCK2CDC42BPA | |
| SCHEMBL2873623 | 0.79 | NPC1 (0.42) | ROCK1ROCK2 | |
| SCHEMBL2876778 | 0.78 | AKT1 (0.41) | ROCK1ROCK2 | |
| SCHEMBL2878622 | 0.77 | MMP13 (0.44) | ROCK1ROCK2 | |
| SCHEMBL2870920 | 0.77 | AKT1 (0.35) | ROCK1ROCK2 | |
| SCHEMBL2877177 | 0.77 | ROCK2 (0.41) | ROCK1ROCK2JAK2 | |
| SCHEMBL2874794 | 0.76 | JAK2 (0.40) | CDC42BPBROCK1ROCK2JAK2CDC42BPA | |
| SCHEMBL2877014 | 0.76 | JAK2 (0.40) | CDC42BPBROCK1ROCK2JAK2CDC42BPA | |
| SCHEMBL2877100 | 0.76 | ROCK2 (0.39) | CDC42BPBROCK1ROCK2 | |
| SCHEMBL2875905 | 0.76 | ROCK2 (0.42) | CDC42BPBROCK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | claimed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | claimed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |