Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.65 |
| ▸ | NAMPT | P43490 | 2/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| O-Xylene SCHEMBL27720472 | 0.93 | BRAF (0.62) | BRAFCSF1RRAB9ACYP11B2 | |
| SCHEMBL3943800 | 0.87 | BRAF (0.80) | BRAFNAMPTCSF1RCYP11B2 | |
| M-Xylene SCHEMBL27720422 | 0.82 | BRAF (0.58) | BRAFNAMPTCSF1RCYP11B2 | |
| SCHEMBL3941714 | 0.81 | BRAF (0.83) | BRAFCSF1R | |
| SCHEMBL3941787 | 0.81 | CSF1R (0.74) | BRAFCSF1RNPC1CYP11B2 | |
| SCHEMBL27720606 | 0.79 | BRAF (0.79) | BRAFNAMPTCSF1RRAB9A | |
| SCHEMBL3937779 | 0.79 | BRAF (1.00) | BRAFCSF1R | |
| SCHEMBL30926779 | 0.79 | NAMPT (0.72) | BRAFNAMPTCSF1R | |
| SCHEMBL27179743 | 0.79 | NAMPT (0.72) | BRAFNAMPTCSF1R | |
| SCHEMBL3937724 | 0.79 | CSF1R (0.83) | BRAFCSF1RNPC1RAB9ACYP11B2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |