Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.62 |
| ▸ | CSF1R | P07333 | 3/20 | 0.57 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | KIT | P10721 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| P-Xylene SCHEMBL28772414 | 0.93 | BRAF (0.65) | BRAFCSF1RCYP11B2RAB9A | |
| SCHEMBL3943800 | 0.82 | BRAF (0.80) | BRAFCSF1RCYP11B2 | |
| SCHEMBL3937724 | 0.81 | CSF1R (0.83) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL13162689 | 0.81 | ALDH1A1 (0.70) | BRAFCYP11B2KDM4EMEN1ALDH1A1 | |
| M-Xylene SCHEMBL27720422 | 0.80 | BRAF (0.58) | BRAFCSF1RCYP11B2 | |
| SCHEMBL27720411 | 0.80 | CYP11B2 (0.76) | BRAFCSF1RCYP11B2MEN1KMT2A | |
| SCHEMBL3941714 | 0.79 | BRAF (0.83) | BRAFCSF1RKITKDRMAPK14 | |
| Bromobenzene SCHEMBL27720387 | 0.78 | CYP11B2 (0.57) | CSF1RCYP11B2KDM4EMEN1ALDH1A1 | |
| SCHEMBL13161982 | 0.78 | BRAF (0.74) | BRAFCSF1RCYP11B2KITKDR | |
| SCHEMBL3934041 | 0.78 | BRAF (0.63) | BRAFCSF1RCYP11B2KITKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128454-A | Pyridine carboxamide derivatives for use as anticancer agents | ASTRAZENECA AB (SE) | 2008-02-20 | — | — | CN | disclosed |