Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 12/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RELA | Q04206 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27837486 | 0.84 | CYP1A2 (0.39) | CCR1CYP17A1CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL4126308 | 0.81 | MAPT (0.50) | CYP17A1CYP1A2CYP11B1CYP11B2NPC1 | |
| SCHEMBL441028 | 0.81 | CYP1A2 (0.54) | CCR1CYP17A1CYP1A2 | |
| SCHEMBL4112054 | 0.76 | SCN9A (0.41) | CCR1CYP17A1CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL441916 | 0.75 | CCR1 (0.46) | CCR1CYP17A1CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL17238733 | 0.74 | CYP11B2 (0.48) | CYP17A1CYP1A2CYP11B1CYP11B2 | |
| SCHEMBL19099014 | 0.73 | NOS1 (0.37) | NPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL17582162 | 0.73 | NPC1 (0.50) | CYP17A1CYP1A2NPC1LMNARAB9A | |
| SCHEMBL2003613 | 0.69 | MAPK14 (0.44) | CCR1 | |
| SCHEMBL27745777 | 0.69 | GRM2 (0.37) | NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101291914-A | Novel bicyclic sulfonamides for use as glucocorticoid receptor modulators in the treatment of inflammatory diseases | ASTRAZENECA AB (SE) | 2008-10-22 | — | — | CN | disclosed |