Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.66 |
| ▸ | KDM5C | P41229 | 3/20 | 0.66 |
| ▸ | KDM6B | O15054 | 2/20 | 0.66 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.66 |
| ▸ | KDM2A | Q9Y2K7 | 2/20 | 0.66 |
| ▸ | KDM3A | Q9Y4C1 | 2/20 | 0.66 |
| ▸ | JMJD6 | Q6NYC1 | 5/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | KDM5A | P29375 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | KDM1A | O60341 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7963734 | 0.91 | KDM4E (0.59) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL29894587 | 0.86 | KDM4E (0.86) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL70279 | 0.86 | KDM4E (0.86) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL13383551 | 0.85 | KDM4E (0.69) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| Hydrochloric Acid SCHEMBL6504834 | 0.84 | KDM4E (0.83) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL6514670 | 0.84 | KDM4E (0.83) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL14291398 | 0.84 | KDM4E (0.52) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL2714272 | 0.84 | KDM4E (0.51) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL2716296 | 0.84 | KDM5B (0.48) | KDM5BKDM4EKDM5CKDM6BKDM4C | |
| SCHEMBL10789252 | 0.83 | SMN1; SMN2 (0.56) | KDM5BKDM4ERAB9ASMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |