Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.83 |
| ▸ | KDM6B | O15054 | 3/20 | 0.83 |
| ▸ | KDM5C | P41229 | 3/20 | 0.83 |
| ▸ | KDM4C | Q9H3R0 | 3/20 | 0.83 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.83 |
| ▸ | KDM3A | Q9Y4C1 | 3/20 | 0.83 |
| ▸ | JMJD6 | Q6NYC1 | 8/20 | 0.71 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | MAOB | P27338 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29894587 | 0.98 | KDM4E (0.86) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL70279 | 0.98 | KDM4E (0.86) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL6514670 | 0.96 | KDM4E (0.83) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL714108 | 0.91 | KDM4E (0.76) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL2868531 | 0.91 | KDM5C (1.00) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL29670732 | 0.91 | KDM5C (1.00) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL19229659 | 0.91 | KDM4E (0.76) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL30774379 | 0.91 | KDM4E (0.76) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL14944871 | 0.90 | KDM4E (0.73) | KDM4EKDM6BKDM5CKDM4CKDM2A | |
| SCHEMBL7033789 | 0.88 | KDM4E (0.71) | KDM4EKDM6BKDM5CKDM4CKDM2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6916606-B2 | Electrochemiluminescent assays | BIOVERIS CORPORATION (US) | 2005-07-12 | — | — | US | disclosed |
| US-6316607-B1 | AS LABLES IN DETECTING AND QUANTIFYING CHEMICAL, BIOCHEMICAL, AND BIOLOGICAL SUBSTANCES, DRUGS, METABOLITES, MICROORGANISMS | IGEN INTERNATIONAL, INC. | 2001-11-13 | — | — | US | disclosed |