Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 11/20 | 0.51 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.51 |
| ▸ | IGF1R | P08069 | 3/20 | 0.49 |
| ▸ | MAOA | P21397 | 2/20 | 0.48 |
| ▸ | MAOB | P27338 | 2/20 | 0.48 |
| ▸ | PIM2 | Q9P1W9 | 9/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | PIM3 | Q86V86 | 2/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.45 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2877348 | 1.00 | PIM1 (0.51) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2880397 | 0.86 | PIM1 (0.55) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2880421 | 0.86 | PIM1 (0.55) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2882644 | 0.84 | PIM1 (0.52) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2882646 | 0.84 | PIM1 (0.52) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2882924 | 0.83 | MAOA (0.67) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL6420710 | 0.77 | HPGD (0.55) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL6420714 | 0.77 | HPGD (0.55) | PIM1AKR1B1IGF1RMAOAMAOB | |
| SCHEMBL2877422 | 0.76 | HPGD (0.57) | PIM1AKR1B1MAOAMAOBPIM2 | |
| SCHEMBL2877423 | 0.76 | HPGD (0.57) | PIM1AKR1B1MAOAMAOBPIM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | disclosed |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | ZAP70, BRCA1, ZYX | PIM1 2247/4885AKR1B1 268/4885IGF1R 291/4885 |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | CATSPER1, PI4KB, MAN2B2 | PIM1 2811/4885AKR1B1 1179/4885IGF1R 3078/4885 |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | BRCA1, ZAP70, F13B | PIM1 2412/4885AKR1B1 264/4885IGF1R 250/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.