Sugi Predict

Sugi Predict / Targets / CATSPER1

CATSPER1

Cation channel sperm-associated protein 1 · Q8NEC5 · CATSPER1 on Sugi Atlas →

151 patent compounds predicted against CATSPER1, 76 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL4792747 SCHEMBL4792747 1.00 2/20
SCHEMBL8242849 SCHEMBL8242849 1.00 2/20
SCHEMBL14948955 SCHEMBL14948955 0.82 2/20
SCHEMBL15891247 SCHEMBL15891247 0.71 2/20
SCHEMBL16706101 SCHEMBL16706101 0.67 2/20
SCHEMBL2117370 SCHEMBL2117370 0.66 2/20
SCHEMBL11605100 SCHEMBL11605100 0.66 2/20
SCHEMBL11602297 SCHEMBL11602297 0.64 2/20
SCHEMBL11602301 SCHEMBL11602301 0.64 2/20
SCHEMBL8370261 SCHEMBL8370261 0.63 2/20
SCHEMBL8251473 SCHEMBL8251473 0.61 2/20
SCHEMBL11604346 SCHEMBL11604346 0.59 2/20
SCHEMBL8372387 SCHEMBL8372387 0.57 2/20
SCHEMBL15891265 SCHEMBL15891265 0.56 2/20
SCHEMBL14765407 SCHEMBL14765407 0.53 2/20
SCHEMBL8738486 SCHEMBL8738486 0.52 2/20
SCHEMBL15891235 SCHEMBL15891235 0.52 2/20
SCHEMBL11150237 SCHEMBL11150237 0.50 2/20
SCHEMBL8243621 SCHEMBL8243621 0.49 2/20
SCHEMBL17286407 SCHEMBL17286407 0.47 2/20

Clinical trials — most relevant to CATSPER1 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Can Calcium Ionophore Application Enhance the ICSI Outcomes in Severe Male Factor Infertility? PHASE2/PHASE3UNKNOWN
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men PHASE3ACTIVE_NOT_RECRUITING
Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial PHASE2/PHASE3COMPLETED
Sodium Citrate in Smell Retraining for People With Post-COVID-19 Olfactory Dysfunction PHASE2ACTIVE_NOT_RECRUITING
A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours PHASE1COMPLETED
Effect of Environmental Exposures on the Egg Fertilizing Ability of Human Sperm nanCOMPLETED
Study of Sperm Molecular Factors Implicated in Male Fertility nanCOMPLETED
Seminal Level of Clusterin Before Testicular Sperm Extraction nanUNKNOWN
Capacitation-associated Protein Tyrosine Phosphorylation As a Possible Biomarker of Sperm Selection nanCOMPLETED
Molecular Markers of Human Sperm Function nanWITHDRAWN
Azoospermia Patients nanRECRUITING
Lipidic Differences of Sperm Between Normal and Low Fertilization Patients nanUNKNOWN
Outcome of Using Sperm Bound to the Zona Pellucida of Immature Oocytes for Intracytoplasmic Sperm Injection (ICSI) nanCOMPLETED
Genetic Causes of Male Infertility nanCOMPLETED
Epididymal U.S Findings in Asthenozoospermic &Correlation With L.Carnitine Level nanUNKNOWN
Vitamin D Level vs Semen Parameters nanUNKNOWN
Human MATER and Idiopathic Infertility nanCOMPLETED
Warfarin Effects on Male Fertility After Cardiac Surgery nanNOT_YET_RECRUITING
Study to Verify the Efficacy of a Product Containing 125 mg of TetraSOD® for the Treatment of Male Infertility nanRECRUITING
Impact of Weight Loss on the Human Sperm Epitranscriptome nanACTIVE_NOT_RECRUITING
The Effects of Diet on Small Non-coding RNA i Sperm Cells and the Possible Effects on Reproductive Success: Diet Intervention Effects on Sperm nanRECRUITING
Novel Approach With Double Agent Artificial Oocyte Activation for Repeated Fertilization Failure Due to Combined Sperm and Oocyte Factor nanCOMPLETED
Study of Gene Associations and Infertility nanENROLLING_BY_INVITATION
Study the Effect of Oral Zinc Supplementation on Enzymes of Nitric Oxide Pathway nanCOMPLETED
Human Sperm Binding to Transgenic Mouse Eggs nanCOMPLETED
Genetic Analyses of Nonsyndromic and Syndromic Deafness in Pakistan nanENROLLING_BY_INVITATION
Reproductive Outcomes After Intracytoplasmic Sperm Injection (ICSI) With Surgically Retrieved Sperm. nanACTIVE_NOT_RECRUITING
Hong Kong Spinocerebellar Ataxias Registry nanRECRUITING
Successful Pregnancy and Delivery After AOA nanCOMPLETED
The Clinical Study of Sex Chromosome Variants nanCOMPLETED

Related proteins — ESM-2 sequence neighbours (a CATSPER1 binder may also engage these)

ProteinNameSimilarity
Q91ZR5 — 0.990 Q91ZR5 →
A6H8H5 — 0.971 A6H8H5 →
Q63099 — 0.970 Q63099 →
Q9BX69 — 0.969 Q9BX69 →
KCNQ2 Potassium voltage-gated channel subfamily KQT member 2 0.969 landscape →
Q96M34 — 0.968 Q96M34 →
Q5M7W4 — 0.967 Q5M7W4 →
Q32NZ6 — 0.967 Q32NZ6 →
Q8N7N6 — 0.966 Q8N7N6 →
Q4ZHA6 — 0.966 Q4ZHA6 →
Q0P6D6 — 0.966 Q0P6D6 →
Q6AXP6 — 0.965 Q6AXP6 →
Q95L11 — 0.965 Q95L11 →
Q68CR7 — 0.965 Q68CR7 →
Q7TQI8 — 0.965 Q7TQI8 →
Q4R989 — 0.965 Q4R989 →
Q8BVV7 — 0.964 Q8BVV7 →
Q76N89 — 0.964 Q76N89 →
Q5W0A0 — 0.963 Q5W0A0 →
Q6P752 — 0.963 Q6P752 →
Q9JKA7 — 0.963 Q9JKA7 →
Q3V0C1 — 0.963 Q3V0C1 →
Q8BW86 — 0.963 Q8BW86 →
Q66HD8 — 0.963 Q66HD8 →
Q70EL1 — 0.962 Q70EL1 →
A6H8Z2 — 0.962 A6H8Z2 →
Q8NDZ2 — 0.962 Q8NDZ2 →
Q96P56 — 0.962 Q96P56 →
KCNQ5 Potassium voltage-gated channel subfamily KQT member 5 0.962 landscape →
Q8K4P8 — 0.962 Q8K4P8 →