Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.59 |
| ▸ | CLK4 | Q9HAZ1 | 8/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 7/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 7/20 | 0.57 |
| ▸ | LMNA | P02545 | 7/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | TSHR | P16473 | 5/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 5/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 2/20 | 0.53 |
| ▸ | PRKDC | P78527 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4147879 | 0.86 | PTK2 (0.59) | PTK2CLK4CYP3A4MAPK1HIF1A | |
| SCHEMBL2882279 | 0.86 | PRKDC (0.47) | LMNAALDH1A1TSHRPRKDCALOX15 | |
| SCHEMBL2882262 | 0.84 | HTT (0.65) | CLK4CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL2882868 | 0.83 | KIT (0.48) | CLK4CYP3A4MAPK1HIF1ALMNA | |
| SCHEMBL2880253 | 0.82 | HTT (0.60) | CLK4LMNACYP1A2ALDH1A1TSHR | |
| SCHEMBL2882078 | 0.82 | ENPP1 (0.48) | CLK4CYP3A4HIF1ALMNACYP1A2 | |
| SCHEMBL2882471 | 0.79 | MEN1 (0.53) | PTK2CLK4CYP3A4MAPK1HIF1A | |
| SCHEMBL2882472 | 0.79 | MEN1 (0.53) | PTK2CLK4CYP3A4MAPK1HIF1A | |
| SCHEMBL4752516 | 0.79 | SMN1; SMN2 (0.55) | MAPK1ALDH1A1PDE10AMEN1KMT2A | |
| SCHEMBL3117120 | 0.79 | HTT (0.70) | PTK2CLK4CYP3A4MAPK1HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7846925-B2 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2010-12-07 | — | — | US | disclosed |
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | LABORATOIRES SERONO S.A. (CH) | 2009-12-10 | — | — | US | disclosed |
| US-20090082349-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION | 2009-03-26 | — | — | US | disclosed |
| EP-1996191-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SmithKline Beecham Corporation (US) | 2008-12-03 | — | — | EP | disclosed |
| US-20080261974-A1 | Novel Chemical Compounds | DUFFY KEVIN J | 2008-10-23 | — | — | US | disclosed |
| EP-1940812-A2 | NOVEL CHEMICAL COMPOUNDS | SmithKline Beecham Corporation (US) | 2008-07-09 | — | — | EP | disclosed |
| WO-2007103759-A2 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |
| WO-2007038331-A2 | NOVEL CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | MERCK SERONO SA (CH) | 2006-06-08 | — | — | US | disclosed |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | APPLIED RESEARCH SYSTEMS ARS HOLDING NV (NL) | 2005-10-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090306069-A1 | AZOLIDINONE-VINYL FUSED-BENZENE DERIVATIVES | ZAP70, BRCA1, ZYX | PTK2 175/4885CLK4 3930/4885CYP3A4 444/4885 |
| US-20080261974-A1 | Novel Chemical Compounds | HIPK3, HIPK1, HIPK4 | PTK2 255/4885CLK4 1506/4885CYP3A4 4844/4885 |
| US-20090082349-A1 | THIAZOLONES FOR USE AS PI3 KINASE INHIBITORS | PIK3CA, BTK, PI4KA | PTK2 45/4885CLK4 2615/4885CYP3A4 1388/4885 |
| US-20050222225-A1 | Use of compounds for increasing spermatozoa motility | CATSPER1, PI4KB, MAN2B2 | PTK2 122/4885CLK4 1537/4885CYP3A4 3896/4885 |
| US-20060122176-A1 | Azolidinone-vinyl fused-benzene derivatives | BRCA1, ZAP70, F13B | PTK2 187/4885CLK4 3861/4885CYP3A4 476/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.