Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 6/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.50 |
| ▸ | DRD1 | P21728 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA4 | P22748 | 1/20 | 0.49 |
| ▸ | CA5A | P35218 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL438555 | 0.81 | CA2 (1.00) | CA2HTTMEN1TSHRKMT2A | |
| SCHEMBL1568393 | 0.78 | HTT (0.66) | CA2HTTALOX5HTR1AADRA2A | |
| SCHEMBL406531 | 0.78 | HTT (0.61) | CA2HTTALOX5HTR1AADRA2A | |
| SCHEMBL9451259 | 0.77 | CA2 (0.64) | CA2HTTALOX5HTR1AADRA2A | |
| SCHEMBL437933 | 0.77 | CA2 (1.00) | CA2CA1LMNAALDH1A1SMN1; SMN2 | |
| SCHEMBL441036 | 0.77 | CA2 (1.00) | CA2CA1LMNAALDH1A1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL8179101 | 0.77 | HTT (0.59) | CA2HTTALOX5HTR1AADRA2A | |
| SCHEMBL12309752 | 0.75 | POLB (0.62) | CA2HTTTSHRHTR1AADRA2A | |
| SCHEMBL8788249 | 0.75 | HTT (0.61) | CA2HTTHTR1AADRA2ADRD1 | |
| SCHEMBL5871673 | 0.75 | HTT (0.61) | CA2HTTALOX5HTR1AADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101378746-B | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain | JANSSEN PHARMACEUTICA NV | 2013-07-17 | — | — | CN | disclosed |
| CN-101336106-B | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression | JANSSEN PHARMACEUTICA NV | 2012-09-05 | — | — | CN | disclosed |
| CN-101374512-B | Use of benzo-fused heterocycle sulfamide for preparing neuroprotective agent | JANSSEN PHARMACEUTICA NV | 2012-07-04 | — | — | CN | disclosed |
| CN-101365442-B | Use of benzo-fused heterocycle sulfamide derivatives for preparing medicine for the treatment of obesity | JANSSEN PHARMACEUTICA NV | 2011-11-16 | — | — | CN | disclosed |
| CN-101365441-B | Use of benzo-fused heterocycle sulfamide derivatives for the preparation of a medicament for lowering lipid levels and lowering blood glucose levels | JANSSEN PHARMACEUTICA NV | 2011-11-16 | — | — | CN | disclosed |
| CN-101370495-B | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of mania and bipolar disorder | JANSSEN PHARMACEUTICA NV | 2011-10-19 | — | — | CN | disclosed |
| CN-101378746-A | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of pain | JANSSEN PHARMACEUTICA NV (BE) | 2009-03-04 | — | — | CN | disclosed |
| CN-101374512-A | Use of benzo-fused heterocycle sulfonamides as neuroprotective agents | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-25 | — | — | CN | disclosed |
| CN-101374513-A | Use of benzo-fused heterocycle sulfamide derivatives for disease remission/epileptogenesis | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-25 | — | — | CN | disclosed |
| CN-101370495-A | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of mania and bipolar disorder | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-101370494-A | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of substance abuse and addiction | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-18 | — | — | CN | disclosed |
| CN-101365442-A | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of obesity | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-11 | — | — | CN | disclosed |
| CN-101365441-A | Use of benzo-fused heterocycle sulfamide derivatives for lowering lipid levels and lowering blood glucose levels | JANSSEN PHARMACEUTICA NV (BE) | 2009-02-11 | — | — | CN | disclosed |
| CN-101336106-A | Use of benzo-fused heterocycle sulfamide derivatives for the treatment of depression | JANSSEN PHARMACEUTICA NV (BE) | 2008-12-31 | — | — | CN | disclosed |