⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6448533 | 0.62 | — | — | |
| SCHEMBL15288703 | 0.58 | — | — | |
| SCHEMBL6429020 | 0.56 | HSP90AA1 (0.33) | — | |
| SCHEMBL3408218 | 0.56 | LOXL2 (0.50) | — | |
| SCHEMBL1257944 | 0.56 | HSP90AA1 (0.33) | — | |
| SCHEMBL168278 | 0.55 | — | — | |
| SCHEMBL3433173 | 0.55 | — | — | |
| SCHEMBL9285426 | 0.53 | MAOB (0.48) | — | |
| SCHEMBL10601030 | 0.52 | — | — | |
| SCHEMBL6429179 | 0.51 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE45004-E1 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-07-08 | — | — | US | disclosed |
| US-RE44987-E1 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2014-07-01 | — | — | US | disclosed |
| EP-2514750-B1 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | SUNSHINE LAKE PHARMA CO LTD (CN) | 2013-11-20 | — | — | EP | disclosed |
| US-8343969-B2 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2013-01-01 | — | — | US | disclosed |
| US-20120282221-A1 | BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2012-11-08 | — | — | US | disclosed |
| EP-2514750-A1 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | Sunshine Lake Pharma Co., Ltd (CN) | 2012-10-24 | — | — | EP | disclosed |
| US-8236797-B2 | Bromo-phenyl substituted thiazolyl dihydropyrimidines | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2012-08-07 | — | — | US | disclosed |
| EP-2159224-B1 | BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES | SUNSHINE LAKE PHARMA CO LTD (CN) | 2012-08-01 | — | — | EP | disclosed |
| US-20100240655-A1 | BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES | Zhong Neng Zhang (CN) | 2010-09-23 | — | — | US | disclosed |
| EP-2159224-A1 | BROMO-PHENYL SUBSTITUTED THIAZOLYL DIHYDROPYRIMIDINES | Zhang, Zhongneng (CN) | 2010-03-03 | — | — | EP | disclosed |
| US-7074784-B2 | Nitrogen compounds such as methyl 4-(2-chloro-4-fluorophenyl) -2-(3,5-difluoropyridin-2-yl)-6-(4-morpholinylmethyl)-1,4-dihydropyrimidine -5-carboxylate, with mixtures of lamivudine and interferons, used as viricides; hepatitis | Goldmann, Siegfried (DE) | 2006-07-11 | — | — | US | disclosed |
| EP-1265889-B1 | MEDICAMENTS AGAINST VIRAL DISEASES | BAYER HEALTHCARE AG (DE) | 2004-06-16 | — | — | EP | disclosed |
| US-20030232842-A1 | Medicaments against viral diseases | SUNSHINE LAKE PHARMA CO., LTD. (CN) | 2003-12-18 | — | — | US | disclosed |
| EP-1265889-A1 | MEDICAMENTS AGAINST VIRAL DISEASES | Bayer Aktiengesellschaft (DE) | 2002-12-18 | — | — | EP | disclosed |
| WO-2001068641-A1 | 6-AMINOALKYL-DIHYDROPYRIMIDINES AND THE USE THEREOF AS MEDICAMENTS AGAINST VIRAL DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-20 | — | — | WO | disclosed |
| WO-2001068640-A1 | MEDICAMENTS AGAINST VIRAL DISEASES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-09-20 | — | — | WO | disclosed |