Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9285426 | 0.84 | MAOB (0.48) | CYP3A4ALDH1A1MAOBTSHRSMN1; SMN2 | |
| SCHEMBL151828 | 0.83 | LOXL2 (0.48) | LOXL2CYP3A4CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL6609419 | 0.79 | — | — | |
| SCHEMBL16992896 | 0.78 | CYP3A4 (0.46) | LOXL2CYP3A4CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL7349692 | 0.78 | CYP3A4 (0.46) | LOXL2CYP3A4CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL7449249 | 0.78 | CYP3A4 (0.46) | LOXL2CYP3A4CYP2D6ALDH1A1CYP1A2 | |
| SCHEMBL6014431 | 0.77 | MAOB (0.70) | LOXL2MAOBTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL370890 | 0.77 | MAOB (0.70) | LOXL2MAOBTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL12655770 | 0.77 | MAOB (0.70) | LOXL2MAOBTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL18662465 | 0.76 | CYP1A2 (0.44) | LOXL2CYP3A4CYP2D6ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2127650-B1 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS INC (US) | 2018-12-05 | — | — | EP | disclosed |
| US-8557979-B2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2013-10-15 | — | — | US | disclosed |
| US-20120296084-A1 | Carbapenem Antibacterials with Gram-Negative Activity and Processes for Their Preparation | FOB SYNTHESIS, INC. (US) | 2012-11-22 | — | — | US | disclosed |
| US-8232268-B2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2012-07-31 | — | — | US | disclosed |
| US-20100160284-A1 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION | FOB SYNTHESIS, INC., (US) | 2010-06-24 | — | — | US | disclosed |
| US-7683049-B2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB SYNTHESIS, INC. (US) | 2010-03-23 | — | — | US | disclosed |
| EP-2127650-A2 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | FOB Synthesis, Inc. (US) | 2009-12-02 | — | — | EP | disclosed |
| EP-1765326-A4 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION | FOB SYNTHESIS INC (US) | 2009-05-13 | — | — | EP | disclosed |
| EP-1765326-A1 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION | FOB Synthesis, Inc. (US) | 2007-03-28 | — | — | EP | disclosed |
| US-20060069081-A1 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | CHOI, WOO-BAEG, DR. | 2006-03-30 | — | — | US | disclosed |
| EP-1105736-B1 | ELECTROCHEMICAL AFFINITY ASSAY | THERASENSE INC (US) | 2002-06-05 | — | — | EP | disclosed |
| US-20020001799-A1 | RAPID AMPEROMETRIC VERIFICATION OF PCR AMPLIFICATION OF DNA | NATIONAL SCIENCE FOUNDATION | 2002-01-03 | — | — | US | disclosed |
| US-6281006-B1 | DETECTING PROTEINS AND NUCLEIC ACIDS; ELECTRODE COATED WITH REDOX POLYMER; BIOCHEMICAL IMMOBILIZATION | THERASENSE, INC. | 2001-08-28 | — | — | US | disclosed |
| EP-1108063-A1 | RAPID AMPEROMETRIC VERIFICATION OF PCR AMPLIFICATION OF DNA | E. HELLER & COMPANY (US) | 2001-06-20 | — | — | EP | disclosed |
| EP-1105736-A1 | ELECTROCHEMICAL AFFINITY ASSAY | Therasense, Inc. (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1090286-A1 | MULTI-SENSOR ARRAY FOR ELECTROCHEMICAL RECOGNITION OF NUCLEOTIDE SEQUENCES AND METHODS | Therasense, Inc. (US) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067628-A9 | MULTI-SENSOR ARRAY FOR ELECTROCHEMICAL RECOGNITION OF NUCLEOTIDE SEQUENCES AND METHODS | HELLER E & CO (US) | 2000-04-06 | — | — | WO | disclosed |
| WO-2000011224-A1 | RAPID AMPEROMETRIC VERIFICATION OF PCR AMPLIFICATION OF DNA | E. HELLER & COMPANY (US) | 2000-03-02 | — | — | WO | disclosed |
| WO-2000011474-A1 | ELECTROCHEMICAL AFFINITY ASSAY | THERASENSE, INC. (US) | 2000-03-02 | — | — | WO | disclosed |
| WO-1999067628-A1 | MULTI-SENSOR ARRAY FOR ELECTROCHEMICAL RECOGNITION OF NUCLEOTIDE SEQUENCES AND METHODS | THERASENSE, INC. (US) | 1999-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120296084-A1 | Carbapenem Antibacterials with Gram-Negative Activity and Processes for Their Preparation | MGAM, GSK3B, GSK3A | LOXL2 4271/4885CYP3A4 1358/4885CYP2D6 1423/4885 |
| US-20060069081-A1 | Carbapenem antibacterials with gram-negative activity and processes for their preparation | MGAM, GSK3B, GSK3A | LOXL2 4271/4885CYP3A4 1358/4885CYP2D6 1423/4885 |
| US-20100160284-A1 | CARBAPENEM ANTIBACTERIALS WITH GRAM-NEGATIVE ACTIVITY AND PROCESSES FOR THEIR PREPARATION | MGAM, GSK3B, GSK3A | LOXL2 4271/4885CYP3A4 1358/4885CYP2D6 1423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.