Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 9/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | ULK1 | O75385 | 5/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27729179 | 0.83 | KDR (0.42) | CDK8FGFR1KDRBRD4AXL | |
| SCHEMBL298532 | 0.82 | CDK8 (0.50) | CDK8FGFR1KDRULK1BRD4 | |
| Propionic Acid SCHEMBL1098913 | 0.81 | CDK8 (0.46) | CDK8KDRCHRNA7ULK1AXL | |
| Ethoxycarbonyl Group SCHEMBL27691273 | 0.78 | KIF11 (0.44) | CHRNA7 | |
| Ethoxycarbonyl Group SCHEMBL27518656 | 0.73 | NUDT1 (0.62) | CDK8FGFR1KDRAXL | |
| SCHEMBL20685730 | 0.71 | CDK8 (0.45) | CDK8FGFR1KDRULK1BRD4 | |
| SCHEMBL18427601 | 0.71 | CDK8 (0.45) | CDK8FGFR1KDRBRD4AXL | |
| Ethoxycarbonyl Group SCHEMBL28284409 | 0.70 | POLB (0.45) | — | |
| Ethoxycarbonyl Group SCHEMBL28282913 | 0.70 | GAA (0.51) | — | |
| SCHEMBL84144 | 0.70 | CDK8 (0.50) | CDK8FGFR1KDRBRD4AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379041-B | Tricyclic N-heteroaryl-carboxamide derivatives containing a benzimidazole structural element, their preparation and their therapeutic use | SANOFI AVENTIS | 2012-08-29 | — | — | CN | disclosed |
| CN-101379041-A | Tricyclic N-heteroaryl-amide derivatives containing benzimidazole structural units, their preparation and their therapeutic use | SANOFI AVENTIS (FR) | 2009-03-04 | — | — | CN | disclosed |