Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 12/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 12/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 12/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 12/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 12/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 12/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.34 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2879664 | 0.93 | MEN1 (0.34) | SLC22A12PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL188869 | 0.88 | F2RL3 (0.36) | MEN1KMT2A | |
| SCHEMBL216705 | 0.88 | PPARG (0.36) | SLC22A12MEN1KMT2A | |
| SCHEMBL218024 | 0.85 | CSF1R (0.35) | MEN1KMT2A | |
| SCHEMBL188969 | 0.85 | MEN1 (0.34) | MEN1KMT2ADPP4 | |
| SCHEMBL188536 | 0.84 | MEN1 (0.36) | MEN1KMT2ADPP4 | |
| SCHEMBL8510234 | 0.84 | MEN1 (0.35) | MEN1KMT2ADPP4 | |
| SCHEMBL219010 | 0.83 | MEN1 (0.37) | MEN1KMT2ADPP4 | |
| SCHEMBL2875942 | 0.83 | MEN1 (0.37) | MEN1KMT2ADPP4 | |
| SCHEMBL216006 | 0.83 | POLB (0.40) | MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288396-B2 | Pyrimidopyrimidoindazole derivative | MSDKK (JP) | 2012-10-16 | — | — | US | disclosed |
| US-20120134955-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | MSD K.K. (JP) | 2012-05-31 | — | — | US | disclosed |
| WO-2010098367-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | BANYU PHARMACEUTICAL CO.,LTD. (JP) | 2010-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120134955-A1 | PYRIMIDOPYRIMIDOINDAZOLE DERIVATIVE | WEE1, WEE2, DCK | SLC22A12 4345/4885PSEN1 4866/4885PSEN2 4860/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.