Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 3/20 | 0.51 |
| ▸ | HTR2C | P28335 | 5/20 | 0.45 |
| ▸ | HTR2A | P28223 | 3/20 | 0.45 |
| ▸ | HTR7 | P34969 | 3/20 | 0.45 |
| ▸ | HTR6 | P50406 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.42 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28779340 | 1.00 | HSD11B1 (0.51) | HSD11B1HTR2CHTR2AHTR7HTR6 | |
| SCHEMBL27758318 | 0.87 | HSD11B1 (0.48) | HSD11B1HTR2CHTR2AHTR7HTR6 | |
| SCHEMBL27758316 | 0.87 | HSD11B1 (0.48) | HSD11B1HTR2CHTR2AHTR7HTR6 | |
| SCHEMBL229148 | 0.84 | HTR2C (0.45) | HTR2CHTR2AHTR7HTR6LMNA | |
| SCHEMBL230362 | 0.84 | HTR2C (0.52) | HTR2CHTR2AHTR7HTR6 | |
| SCHEMBL27737546 | 0.84 | HTR2C (0.52) | HTR2CHTR2AHTR7HTR6 | |
| SCHEMBL228591 | 0.83 | HTR2C (0.46) | HTR2CHTR2AHTR7HTR6LMNA | |
| SCHEMBL230298 | 0.82 | HTR2C (0.45) | HTR2CHTR2AHTR7HTR6LMNA | |
| SCHEMBL227200 | 0.82 | LMNA (0.46) | HTR2CHTR2AHTR7HTR6LMNA | |
| SCHEMBL229122 | 0.81 | HTR2C (0.44) | HTR2CHTR2AHTR7HTR6LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101384581-B | Benzoyl-piperidine derivatives as 5HT2/D3 modulators | HOFFMANN LA ROCHE | 2013-09-18 | — | — | CN | claimed |
| CN-101384581-A | Benzoyl-piperidine derivatives as 5HT2/D3 modulators | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | claimed |
| CN-101384581-B | Benzoyl-piperidine derivatives as 5HT2/D3 modulators | HOFFMANN LA ROCHE | 2013-09-18 | — | — | CN | disclosed |
| CN-101384581-A | Benzoyl-piperidine derivatives as 5HT2/D3 modulators | HOFFMANN LA ROCHE (CH) | 2009-03-11 | — | — | CN | disclosed |