Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | KMO | O15229 | 1/20 | 0.55 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.46 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.46 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.46 |
| ▸ | FEN1 | P39748 | 1/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | RXRB | P28702 | 1/20 | 0.44 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.44 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.44 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27998334 | 0.96 | TDP1 (0.65) | ALDH1A1MAPK1TDP1KMOGPR52 | |
| SCHEMBL503007 | 0.86 | TDP1 (0.68) | ALDH1A1MAPK1TDP1HDAC8GAA | |
| SCHEMBL11533689 | 0.85 | ALDH1A1 (0.56) | ALDH1A1MAPK1TDP1KMOGPR52 | |
| SCHEMBL16111856 | 0.82 | KMO (0.69) | ALDH1A1KMOERN1 | |
| SCHEMBL27580030 | 0.82 | ALDH1A1 (0.62) | ALDH1A1MAPK1TDP1GPR52TRIM24 | |
| SCHEMBL8431770 | 0.79 | AKT1 (0.57) | ALDH1A1MAPK1TDP1KMOGPR52 | |
| SCHEMBL29860752 | 0.79 | KAT6A (0.50) | ALDH1A1MAPK1TDP1ERN1 | |
| SCHEMBL3539849 | 0.78 | CA12 (0.59) | ALDH1A1MAPK1TDP1 | |
| SCHEMBL5556723 | 0.78 | TDP1 (0.64) | ALDH1A1MAPK1TDP1KMOERN1 | |
| SCHEMBL15309589 | 0.77 | ALDH1A1 (0.52) | ALDH1A1MAPK1TDP1KMOERN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421261-B | Tetracyclic steroid derivatives useful as progesterone receptor modulators | JANSSEN PHARMACEUTICA NV | 2013-01-23 | — | — | CN | disclosed |
| CN-101421261-A | Tetracyclic steroid derivatives useful as progesterone receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2009-04-29 | — | — | CN | disclosed |