Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxindole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHR | P35869 | 4/20 | 0.66 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.66 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.49 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.47 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | CASP9 | P55211 | 1/20 | 0.41 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Oxindole SCHEMBL3866757 | 0.94 | AHR (0.75) | AHRPDK2PDE3BPDE3ACYP1A2 | |
| Oxindole SCHEMBL28298966 | 0.88 | AHR (0.84) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL3802438 | 0.87 | AHR (0.81) | AHRPDK2PDE3BPDE3ACYP1A2 | |
| Oxindole SCHEMBL14324689 | 0.83 | AHR (0.75) | AHRPDK2PDE3BPDE3ACYP1A2 | |
| Oxindole SCHEMBL29260649 | 0.83 | AHR (0.95) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL28796829 | 0.82 | AHR (0.78) | AHRPDK2NPC1MAPK13MAPK12 | |
| Oxindole SCHEMBL29358826 | 0.81 | AHR (1.00) | AHRPDK2PDE3BPDE3ANPC1 | |
| Oxindole SCHEMBL19504 | 0.81 | AHR (1.00) | AHRPDK2PDE3BPDE3ANPC1 | |
| Oxindole SCHEMBL1144643 | 0.81 | AHR (1.00) | AHRPDK2PDE3BPDE3ANPC1 | |
| Biphenyl SCHEMBL29191442 | 0.79 | AHR (0.88) | AHRPDK2PDE3BPDE3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101437692-B | Printing spacer material | ASAHI CHEMICAL CORP (JP) | 2011-02-02 | — | — | CN | disclosed |
| CN-101437692-A | Printing spacer material | ASAHI CHEMICAL CORP (JP) | 2009-05-20 | — | — | CN | disclosed |