Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 2/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | F9 | P00740 | 1/20 | 0.39 |
| ▸ | GCGR | P47871 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27806948 | 0.82 | DPP4 (0.53) | HIF1ADPP4F10KDM4EL3MBTL1 | |
| SCHEMBL19794412 | 0.81 | MAPK1 (0.56) | MAPK1DYRK1AAKT1AKT2KDM4E | |
| SCHEMBL27772735 | 0.78 | MAPK1 (0.53) | MAPK1HIF1ADYRK1AKDM4EL3MBTL1 | |
| SCHEMBL11041168 | 0.77 | MAPK1 (0.59) | MAPK1HIF1ADYRK1AKDM4EL3MBTL1 | |
| SCHEMBL14007487 | 0.77 | DPP4 (0.49) | DPP4L3MBTL1 | |
| SCHEMBL2329789 | 0.74 | MAPK1 (0.59) | MAPK1HIF1ADYRK1AKDM4EL3MBTL1 | |
| SCHEMBL8279412 | 0.74 | DPP4 (0.53) | DPP4F10 | |
| SCHEMBL15671420 | 0.74 | KMT2A (0.53) | MAPK1HIF1AROCK2AKT1KDM4E | |
| SCHEMBL1298969 | 0.74 | GRM5 (0.58) | MAPK1DYRK1AKDM4EL3MBTL1 | |
| SCHEMBL27378863 | 0.73 | ROCK2 (0.60) | DPP4ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101511789-B | 5, 6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and their use in therapy as urotensin II receptor antagonists | SANOFI AVENTIS | 2012-05-23 | — | — | CN | disclosed |
| CN-101511789-A | 5, 6-bisaryl-2-pyridine-carboxamide derivatives, their preparation and their use in therapy as urotensin II receptor antagonists | SANOFI AVENTIS (FR) | 2009-08-19 | — | — | CN | disclosed |