Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Methenamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methenamine SCHEMBL11043430 | 1.00 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL8990170 | 1.00 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL33785 | 0.93 | KDM4E (0.33) | KDM4E | |
| Methenamine SCHEMBL1229796 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL1157990 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL1538938 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL8519872 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL320310 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL1627716 | 0.86 | KDM4E (0.31) | KDM4E | |
| Methenamine SCHEMBL11683575 | 0.86 | KDM4E (0.31) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010018418-A1 | FORMULATION BASED ON MICRONIZED CLINOPTILOLITE AS THERAPEUTIC AGENT PROVIDING HIGHLY BIOAVAILABLE SILICON | NOVATECH D.O.O. (HR) | 2010-02-18 | — | — | WO | claimed |
| WO-2010018418-A1 | FORMULATION BASED ON MICRONIZED CLINOPTILOLITE AS THERAPEUTIC AGENT PROVIDING HIGHLY BIOAVAILABLE SILICON | NOVATECH D.O.O. (HR) | 2010-02-18 | — | — | WO | disclosed |