Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Methenamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methenamine SCHEMBL1901976 | 0.94 | — | — | |
| Methenamine SCHEMBL1261085 | 0.94 | — | — | |
| Methenamine SCHEMBL541058 | 0.94 | — | — | |
| Methenamine SCHEMBL4306948 | 0.94 | — | — | |
| Methenamine SCHEMBL3412566 | 0.94 | — | — | |
| Methenamine SCHEMBL2988857 | 0.94 | — | — | |
| Methenamine SCHEMBL388812 | 0.94 | — | — | |
| Methenamine SCHEMBL5033140 | 0.94 | — | — | |
| Methenamine SCHEMBL6697487 | 0.94 | — | — | |
| Methenamine SCHEMBL8901393 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3504232-A1 | COMBINATION WITH ALBUMIN, IN PARTICULAR FOR TREATING A CARTILAGE DEFECT | TETEC Tissue Engineering Technologies AG (DE) | 2019-07-03 | — | — | EP | disclosed |
| WO-2018041784-A1 | COMBINATION WITH ALBUMIN, IN PARTICULAR FOR TREATING A CARTILAGE DEFECT | TETEC TISSUE ENGINEERING TECHNOLOGIES AG (DE) | 2018-03-08 | — | — | WO | disclosed |
| EP-1893697-B1 | NITROSULFIDE DYES | BASF SE (DE) | 2014-04-23 | — | — | EP | disclosed |
| US-20140073778-A9 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2014-03-13 | — | — | US | disclosed |
| US-20130184454-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2013-07-18 | — | — | US | disclosed |
| EP-2591008-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | Fresenius Kabi Deutschland GmbH (DE) | 2013-05-15 | — | — | EP | disclosed |
| EP-1937780-B1 | MIXTURE OF SULFIDE DYES | BASF SE (DE) | 2013-02-13 | — | — | EP | disclosed |
| CN-101203573-B | Nitrosulfide dyes | CIBA SPEC CHEM CORP | 2012-05-30 | — | — | CN | disclosed |
| WO-2012004008-A1 | CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION | FRESENIUS KABI DEUTSCHLAND GMBH (DE) | 2012-01-12 | — | — | WO | disclosed |
| EP-1937780-A2 | MIXTURE OF SULFIDE DYES | Ciba Holding Inc. (CH) | 2008-07-02 | — | — | EP | disclosed |
| EP-1893697-A2 | NITROSULFIDE DYES | CIBA SPECIALTY CHEMICALS HOLDING INC. Patent Departement (CH) | 2008-03-05 | — | — | EP | disclosed |
| WO-2006136617-A2 | MIXTURE OF SULFIDE DYES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-12-28 | — | — | WO | disclosed |
| WO-2006136518-A2 | NITROSULFIDE DYES | CIBA SPECIALTY CHEMICALS HOLDING INC. (CH) | 2006-12-28 | — | — | WO | disclosed |
| WO-2003099242-A1 | COSMETIC AGENTS CONTAINING PROTEIN DISULFIDE ISOMERASE | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2003-12-04 | — | — | WO | disclosed |
| EP-0979108-A2 | STENTS WITH A RADIOACTIVE SURFACE COATING, PROCESSES FOR PRODUCING THE SAME AND THEIR USE FOR RESTENOSIS PREVENTION | SCHERING AKTIENGESELLSCHAFT (DE) | 2000-02-16 | — | — | EP | disclosed |
| WO-1998048851-A2 | STENTS WITH A RADIOACTIVE SURFACE COATING | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-11-05 | — | — | WO | disclosed |
| EP-0312086-B1 | Polysulfuric esters of amides of bis-aldonic acids and their derivatives, a method for their preparation and a drug | LUITPOLD PHARMA GMBH (DE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0312087-B1 | AMIDES OF BIS-ALDONIC ACIDS AND A METHOD FOR THEIR PREPARATION | LUITPOLD PHARMA GmbH (DE) | 1993-09-15 | — | — | EP | disclosed |
| EP-0312087-A2 | Amides of bis-aldonic acids and a method for their preparation | LUITPOLD PHARMA GmbH (DE) | 1989-04-19 | — | — | EP | disclosed |
| EP-0312086-A2 | Polysulfuric esters of amides of bis-aldonic acids and their derivatives, a method for their preparation and a drug | LUITPOLD PHARMA GmbH (DE) | 1989-04-19 | — | — | EP | disclosed |