Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | NPC1 | O15118 | 7/20 | 0.57 |
| ▸ | RAB9A | P51151 | 7/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.57 |
| ▸ | HPGD | P15428 | 5/20 | 0.57 |
| ▸ | PKM | P14618 | 3/20 | 0.57 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.57 |
| ▸ | IKBKB | O14920 | 4/20 | 0.52 |
| ▸ | CHUK | O15111 | 4/20 | 0.52 |
| ▸ | AKT1 | P31749 | 4/20 | 0.52 |
| ▸ | AKT2 | P31751 | 4/20 | 0.52 |
| ▸ | AKT3 | Q9Y243 | 4/20 | 0.52 |
| ▸ | PADI4 | Q9UM07 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 6/20 | 0.51 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9453485 | 0.85 | RAB9A (0.63) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9453486 | 0.85 | RAB9A (0.63) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL5117216 | 0.85 | CYP3A4 (0.54) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL22333163 | 0.84 | SMN1; SMN2 (0.57) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1086983 | 0.80 | ALDH1A1 (0.81) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL29539476 | 0.80 | ALDH1A1 (0.81) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL1086985 | 0.80 | ALDH1A1 (0.81) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28352418 | 0.80 | SMN1; SMN2 (0.53) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6598420 | 0.77 | ALDH1A1 (0.65) | ALDH1A1NPC1RAB9AMEN1KMT2A | |
| SCHEMBL11325644 | 0.74 | NPC1 (0.57) | ALDH1A1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1980561-B1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2013-10-09 | — | — | EP | disclosed |
| EP-2002836-B1 | Cyclocondensed azaindoles active as kinase inhibitors | NERVIANO MEDICAL SCIENCES SRL (IT) | 2010-10-20 | — | — | EP | disclosed |
| EP-2070928-A1 | 7-azaindol-3-ylacrylamides active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2009-06-17 | — | — | EP | disclosed |
| EP-2002836-A1 | Cyclocondensed azaindoles active as kinase inhibitors | Nerviano Medical Sciences S.r.l. (IT) | 2008-12-17 | — | — | EP | disclosed |
| EP-1980561-A1 | Substituted 1h-pyrazolo[3,4-b] pyridine derivatives active as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.r.l. (IT) | 2008-10-15 | — | — | EP | disclosed |