Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 5/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.38 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.38 |
| ▸ | IKBKB | O14920 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.36 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23111537 | 0.72 | HRH1 (0.48) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| SCHEMBL8598701 | 0.70 | GABRA1 (0.44) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| SCHEMBL30979860 | 0.70 | MAPK8 (0.54) | PLA2G10PLA2G2A | |
| SCHEMBL7496907 | 0.70 | SLC6A2 (0.60) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| SCHEMBL20400462 | 0.69 | PARP1 (0.44) | HTR1ASLC6A2SLC6A4SLC6A3IKBKB | |
| Hydrochloric Acid SCHEMBL11195226 | 0.68 | SLC6A2 (0.59) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| Hydrochloric Acid SCHEMBL11200015 | 0.68 | SLC6A2 (0.59) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| SCHEMBL15533083 | 0.68 | PARP1 (0.44) | HTR1ASLC6A2SLC6A4SLC6A3IKBKB | |
| SCHEMBL12467974 | 0.68 | GABRA1 (0.43) | GABRA1GABRG2GABRB3HRH1GABRB2 | |
| SCHEMBL21714170 | 0.68 | LIMK1 (0.51) | IKBKBCHUKSLC18A3SIGMAR1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102056933-B | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV | 2014-09-17 | — | — | CN | claimed |
| CN-102056933-A | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | JANSSEN PHARMACEUTICA NV | 2011-05-11 | — | — | CN | claimed |