Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 19/20 | 0.57 |
| ▸ | GRK5 | P34947 | 2/20 | 0.52 |
| ▸ | FLT3 | P36888 | 3/20 | 0.52 |
| ▸ | GRK2 | P25098 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2386880 | 0.90 | MET (0.64) | METGRK5FLT3GRK2 | |
| SCHEMBL2384748 | 0.89 | MET (0.61) | METGRK5FLT3GRK2 | |
| SCHEMBL2386041 | 0.86 | MET (0.70) | METGRK5FLT3GRK2 | |
| SCHEMBL27830004 | 0.85 | MET (0.76) | MET | |
| SCHEMBL2387276 | 0.82 | MET (0.65) | METGRK5FLT3GRK2 | |
| SCHEMBL2385248 | 0.82 | MET (0.67) | METGRK5FLT3GRK2 | |
| SCHEMBL2387375 | 0.78 | MET (0.64) | METGRK5FLT3GRK2 | |
| SCHEMBL27830262 | 0.77 | GRK5 (0.68) | METGRK5FLT3GRK2 | |
| SCHEMBL27829963 | 0.77 | MET (0.52) | METFLT3 | |
| SCHEMBL2386407 | 0.76 | MET (0.63) | METGRK5FLT3GRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101910158-A | Pyridine and pyrazine derivatives useful in the treatment of cell proliferative disorders | ASTRAZENECA AB | 2010-12-08 | — | — | CN | disclosed |