Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX3 | P56373 | 11/20 | 0.48 |
| ▸ | P2RX2 | Q9UBL9 | 10/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278031 | 1.00 | P2RX3 (0.48) | P2RX3P2RX2CYP2C9HDAC4MAP4K4 | |
| SCHEMBL2273906 | 0.94 | P2RX3 (0.48) | P2RX3P2RX2CYP2C9HDAC4MAP4K4 | |
| SCHEMBL2277313 | 0.92 | P2RX3 (0.49) | P2RX3P2RX2CYP2C9MAP4K4AHR | |
| SCHEMBL27830176 | 0.90 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL2272068 | 0.90 | P2RX3 (0.59) | P2RX3P2RX2 | |
| SCHEMBL2273162 | 0.89 | P2RX3 (0.49) | P2RX3P2RX2MAP4K4AHR | |
| SCHEMBL4318767 | 0.89 | P2RX3 (0.46) | P2RX3P2RX2CYP2C9HDAC4MAP4K4 | |
| SCHEMBL27748147 | 0.89 | P2RX3 (0.46) | P2RX3P2RX2CYP2C9HDAC4MAP4K4 | |
| SCHEMBL2272715 | 0.89 | P2RX3 (0.47) | P2RX3P2RX2MAP4K4AHR | |
| SCHEMBL2272521 | 0.89 | P2RX3 (0.47) | P2RX3P2RX2MAP4K4AHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101903359-A | Triazole-substituted arylamide derivatives and their use as P2X3And/or P2X2/3Use of purinergic receptor antagonists | HOFFMANN LA ROCHE | 2010-12-01 | — | — | CN | disclosed |