Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.33 |
| ▸ | CA3 | P07451 | 2/20 | 0.31 |
| ▸ | CA5A | P35218 | 2/20 | 0.31 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA6 | P23280 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.31 |
| ▸ | TOP1 | P11387 | 1/20 | 0.31 |
| ▸ | TOP2A | P11388 | 1/20 | 0.31 |
| ▸ | GLA | P06280 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL236355 | 0.84 | IDO1 (0.41) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL609947 | 0.82 | HPGD (0.36) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL236290 | 0.80 | NQO2 (0.43) | ALDH1A1MTNR1AMTNR1BHPGD | |
| SCHEMBL236921 | 0.77 | CNR1 (0.41) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2754703 | 0.77 | CNR1 (0.41) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL27776417 | 0.77 | ALDH1A1 (0.35) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL27785073 | 0.73 | MTNR1A (0.35) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL2204623 | 0.73 | CNR1 (0.51) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL236805 | 0.73 | CNR1 (0.51) | ALDH1A1SMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL4569062 | 0.73 | HIF1A (0.47) | MTNR1AMTNR1BCNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101917980-A | Amine derivative compounds for the treatment of ophthalmic diseases and disorders | ACUCELA INC | 2010-12-15 | — | — | CN | disclosed |