Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ethylene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.30 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.30 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.30 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.30 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CCL2 | P13500 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.30 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.30 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | HTR2C | P28335 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylene SCHEMBL4323086 | 0.96 | HTR2A (0.41) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| Hydrochloric Acid SCHEMBL29573673 | 0.96 | HTR2A (0.39) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| Hydrochloric Acid SCHEMBL819246 | 0.96 | HTR2A (0.39) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| Hydrochloric Acid SCHEMBL8713393 | 0.94 | HTR2A (0.38) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| SCHEMBL4576220 | 0.91 | HTR2A (0.39) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| Fluoride Ion SCHEMBL7641581 | 0.91 | HTR2A (0.39) | HTR2AHTR6SIGMAR1BRD4CCL2 | |
| Hydrochloric Acid SCHEMBL7640026 | 0.85 | HTR6 (0.33) | HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL30297986 | 0.82 | HTR6 (0.33) | HTR2AHTR6 | |
| Hydrochloric Acid SCHEMBL7936183 | 0.82 | HTR6 (0.31) | HTR2AHTR6SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6918930 | 0.81 | HTR6 (0.33) | HTR2AHTR6KDM4ELMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7592403-B2 | Ethylene polymer, preparation process thereof and molded articles of the same | MITSUI CHEMICALS, INC. (JP) | 2009-09-22 | — | — | US | claimed |
| US-6127305-A | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.P.A (IT) | 2000-10-03 | — | — | US | claimed |
| EP-0588404-B1 | Catalyst and process for polymerizing alpha-olefins | ENICHEM SPA (IT) | 1997-06-18 | — | — | EP | claimed |
| EP-0588404-A2 | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.p.A. (IT) | 1994-03-23 | — | — | EP | claimed |
| US-20240191011-A1 | ETHYLENE-alpha-OLEFIN COPOLYMER, THERMOPLASTIC RESIN COMPOSITION, AND FILM | MITSUI CHEMICALS, INC. (JP) | 2024-06-13 | — | — | US | disclosed |
| EP-4316834-A1 | ETHYLENE-a-OLEFIN COPOLYMER, THERMOPLASTIC RESIN COMPOSITION, AND FILM | Mitsui Chemicals, Inc. (JP) | 2024-02-07 | — | — | EP | disclosed |
| CN-112745403-B | Preparation method of poly-alpha-olefin | 中国石油化工股份有限公司 | 2023-02-17 | — | — | CN | disclosed |
| CN-112745415-B | Method for preparing poly-alpha-olefin with high viscosity index | 中国石油化工股份有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-112745403-A | Preparation method of poly-alpha-olefin | 中国石油化工股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| CN-112745415-A | Method for preparing poly-alpha-olefin with high viscosity index | 中国石油化工股份有限公司 | 2021-05-04 | — | — | CN | disclosed |
| US-7858723-B2 | Ethylene-based resin and molded object obtained therefrom | MITSUI CHEMICALS, INC. (JP) | 2010-12-28 | — | — | US | disclosed |
| EP-2220128-A1 | PROCESS FOR PREPARATION OF POLYOLEFINS VIA LIVING COORDINATIVE CHAIN TRANSFER POLYMERIZATION | University of Maryland, College Park (US) | 2010-08-25 | — | — | EP | disclosed |
| EP-0748824-A1 | High stereoregular polypropylenes | CHISSO CORPORATION (JP) | 1996-12-18 | — | — | EP | disclosed |
| EP-0284707-B1 | Hafnium metallocene catalyst for the polymerization of olefins | FINA TECHNOLOGY (US) | 1995-08-30 | — | — | EP | disclosed |
| EP-0588404-A2 | Catalyst and process for polymerizing alpha-olefins | ENICHEM S.p.A. (IT) | 1994-03-23 | — | — | EP | disclosed |
| EP-0422703-B1 | CATALYST AND PROCESS FOR THE POLYMERIZATION AND COPOLYMERIZATION OF ALPHA-OLEFINS | Enichem Anic S.r.l. (IT) | 1993-06-30 | — | — | EP | disclosed |
| EP-0530908-A1 | Process for the preparation of a bridged metallocene compound as well as a catalyst component and a process for the polymerization of olefins | DSM N.V. (NL) | 1993-03-10 | — | — | EP | disclosed |
| EP-0513808-A2 | Olefin polymerization | PHILLIPS PETROLEUM COMPANY (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5128295-A | Hafnium-titanium-zirconium compound with trialkylaluminum and distannoxane | ENICHEM ANIC S.P.A. (IT) | 1992-07-07 | — | — | US | disclosed |
| EP-0422703-A1 | Catalyst and process for the polymerization and copolymerization of alpha-olefins | Enichem Anic S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |