Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.52 |
| ▸ | SLC6A9 | P48067 | 5/20 | 0.47 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL387616 | 0.89 | GPR119 (0.60) | GPR119SLC6A9BRD4CYP2C9 | |
| SCHEMBL3844161 | 0.86 | GPR119 (0.55) | GPR119 | |
| SCHEMBL387221 | 0.85 | GPR119 (0.60) | GPR119SLC6A9 | |
| SCHEMBL2881115 | 0.84 | GPR119 (0.52) | GPR119 | |
| SCHEMBL2876265 | 0.82 | GPR119 (0.56) | GPR119 | |
| SCHEMBL2881370 | 0.82 | GPR119 (0.51) | GPR119SLC6A9CYP2C9 | |
| SCHEMBL2883378 | 0.81 | GPR119 (0.56) | GPR119 | |
| SCHEMBL2881337 | 0.80 | GPR119 (0.56) | GPR119 | |
| SCHEMBL388495 | 0.79 | GPR119 (0.58) | GPR119CYP2C9KCNH2 | |
| SCHEMBL4053229 | 0.78 | GPR119 (0.61) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2010512334-A | — | — | 2010-04-22 | — | — | JP | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | claimed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | claimed |
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |