Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 15/20 | 0.55 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | GPR183 | P32249 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2881232 | 0.90 | GPR119 (0.61) | GPR119GPR183 | |
| SCHEMBL2881607 | 0.90 | GPR119 (0.58) | GPR119GPR183 | |
| SCHEMBL2881337 | 0.89 | GPR119 (0.56) | GPR119CHRM2CHRM1GPR183 | |
| SCHEMBL2876265 | 0.88 | GPR119 (0.56) | GPR119GPR183 | |
| SCHEMBL2881115 | 0.88 | GPR119 (0.52) | GPR119CHRM2CHRM1 | |
| SCHEMBL2881370 | 0.88 | GPR119 (0.51) | GPR119MMP13 | |
| SCHEMBL387564 | 0.87 | GPR119 (0.69) | GPR119 | |
| SCHEMBL2876156 | 0.87 | GPR119 (0.58) | GPR119MMP13 | |
| SCHEMBL2883378 | 0.87 | GPR119 (0.56) | GPR119 | |
| SCHEMBL2879359 | 0.86 | GPR119 (0.52) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094683-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SmithKline Beecham Corporation (US) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008070692-A2 | BICYCLIC COMPOUNDS AND USE AS ANTIDIABETICS | SMITHKLINE BEECHAM CORPORATION (US) | 2008-06-12 | — | — | WO | disclosed |