Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.34 |
| ▸ | EZH2 | Q15910 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 2/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | PLAT | P00750 | 1/20 | 0.31 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28797463 | 0.85 | EZH2 (0.33) | TDP1ALDH1A1MEN1MAPTPKM | |
| SCHEMBL28797464 | 0.83 | GPR119 (0.30) | GPR119 | |
| Tert-Butyl Formate SCHEMBL27797759 | 0.83 | CHRNB2 (0.42) | TDP1ALDH1A1MEN1MAPTPKM | |
| Tert-Butyl Formate SCHEMBL27869186 | 0.82 | PLAT (0.43) | ALDH1A1MEN1KMT2AEZH2GPR119 | |
| Tert-Butyl Formate SCHEMBL28094448 | 0.78 | TDP1 (0.48) | TDP1ALDH1A1MEN1MAPTPKM | |
| SCHEMBL28794485 | 0.76 | EZH2 (0.35) | TDP1ALDH1A1MEN1MAPTPKM | |
| Tert-Butyl Formate SCHEMBL27825740 | 0.74 | CYP1A2 (0.40) | CHRNB2CHRNA4 | |
| SCHEMBL1055384 | 0.73 | GPR119 (0.50) | PKMEZH2GPR119NR3C1 | |
| Tert-Butyl Formate SCHEMBL28801288 | 0.72 | DDB1 (0.34) | TDP1KDM1A | |
| Tert-Butyl Formate SCHEMBL28782975 | 0.72 | NSD3 (0.35) | TDP1ALDH1A1MEN1MAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459222-A | L- (piperidin-4-yl) -pyrazole derivatives as GPR119 modulators | PFIZER | 2012-05-16 | — | — | CN | disclosed |