Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK9 | P50750 | 1/20 | 0.51 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.49 |
| ▸ | AR | P10275 | 6/20 | 0.47 |
| ▸ | BTK | Q06187 | 2/20 | 0.46 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.46 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.44 |
| ▸ | ALK | Q9UM73 | 3/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28795285 | 0.98 | CRBN (0.50) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL28795213 | 0.97 | CRBN (0.49) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL31458558 | 0.96 | CRBN (0.54) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL28795182 | 0.96 | CRBN (0.54) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL28795391 | 0.96 | CRBN (0.54) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL28795197 | 0.94 | CRBN (0.47) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL27162299 | 0.93 | CDK9 (0.51) | CDK9CRBNARBTKIRAK1 | |
| SCHEMBL29803017 | 0.92 | CRBN (0.56) | CDK9CRBNARBTKBRD9 | |
| SCHEMBL28795113 | 0.92 | CRBN (0.56) | CDK9CRBNARBTKBRD9 | |
| SCHEMBL28795140 | 0.92 | CRBN (0.52) | CDK9CRBNARBTKBRD9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |