Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28795429 | 0.96 | SMN1; SMN2 (0.48) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL25338911 | 0.87 | MAPT (0.43) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL31155399 | 0.86 | GPR174 (0.44) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795264 | 0.86 | CNR1 (0.45) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795202 | 0.85 | SMN1; SMN2 (0.45) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL25339886 | 0.85 | GPR174 (0.47) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795204 | 0.83 | SMN1; SMN2 (0.47) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795349 | 0.83 | MAPT (0.44) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795172 | 0.82 | MAPT (0.44) | MAPTALDH1A1LMNASMN1; SMN2GAA | |
| SCHEMBL28795212 | 0.82 | SMN1; SMN2 (0.39) | MAPTALDH1A1LMNASMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |