SCHEMBL28795205

SCHEMBL28795205

Cc1cc(Br)cc(C)c1COCc1c(C)cc(Br)cc1C

nearest known ligand 0.39

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
HTR1D P28221 1/20 0.39
HTR1B P28222 1/20 0.39
MAOA P21397 1/20 0.34
DRD4 P21917 1/20 0.34
DRD3 P35462 1/20 0.34
IDO1 P14902 1/20 0.33
MEN1 O00255 2/20 0.32
KMT2A Q03164 2/20 0.32
ALDH1A1 P00352 2/20 0.32
KDM4E B2RXH2 1/20 0.32
CYP1A2 P05177 1/20 0.32
CYP2D6 P10635 1/20 0.32
NQO2 P16083 1/20 0.31
TACR1 P25103 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL23638591 0.83 HPGD (0.42) HTR1DHTR1BIDO1MEN1KMT2A
SCHEMBL7890511 0.79 HRH3 (0.39) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL29082171 0.76 HTR1D (0.38) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL14709472 0.74 HTR1D (0.33) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL12305002 0.74 HTR1D (0.41) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL21749452 0.74 HTR1D (0.41) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL29021148 0.73 NQO1 (0.42) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL29082172 0.73 HTR1D (0.36) HTR1DHTR1BMEN1KMT2AALDH1A1
SCHEMBL12002465 0.72 HTR1D (0.35) HTR1DHTR1B
SCHEMBL7969500 0.72 HTR1D (0.40) HTR1DHTR1BDRD4MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114853795-A Arylboron compound of conjugated olefin and preparation method and application thereof 南京工业大学 2022-08-05 CN claimed
CN-114853795-A Arylboron compound of conjugated olefin and preparation method and application thereof 南京工业大学 2022-08-05 CN disclosed
CN-101580518-B Process for preparing diphosphine compounds and intermediates useful in the process TAKEDA CHEMICAL INDUSTRIES LTD 2012-05-23 CN disclosed