Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.42 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24206633 | 0.92 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL29803097 | 0.92 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL29788218 | 0.91 | EGFR (0.52) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL21133577 | 0.91 | EGFR (0.52) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL29060016 | 0.90 | EGFR (0.51) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL14406656 | 0.88 | EGFR (0.52) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL29803089 | 0.88 | EGFR (0.52) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL1707770 | 0.88 | MAPT (0.57) | ALDH1A1LMNAMAPTALKGPR119 | |
| SCHEMBL28795317 | 0.84 | HDAC1 (0.48) | ALKGPR119PDE4B | |
| SCHEMBL28795348 | 0.84 | ALDH1A1 (0.53) | ALDH1A1LMNAMAPTALKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |