Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.51 |
| ▸ | ALK | Q9UM73 | 5/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25370804 | 0.92 | SIRT6 (0.56) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL517794 | 0.91 | ALDH1A1 (0.55) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL310364 | 0.89 | SIRT6 (0.55) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL29802982 | 0.89 | MAPT (0.65) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL310369 | 0.89 | MAPT (0.65) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL310101 | 0.84 | GPR119 (0.59) | ALDH1A1LMNAMAPTSIRT6GPR119 | |
| SCHEMBL28795341 | 0.84 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTALKEGFR | |
| SCHEMBL17411227 | 0.83 | ALDH1A1 (0.59) | ALDH1A1LMNAMAPTSIRT6ALK | |
| SCHEMBL29986023 | 0.82 | MAPT (0.76) | ALDH1A1LMNAMAPTGPR119 | |
| SCHEMBL28945679 | 0.81 | ALDH1A1 (0.54) | ALDH1A1LMNAMAPTSIRT6ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805303-A | Molecule with double functions of degrading EGFR (epidermal growth factor receptor), composition and pharmaceutical application thereof | 海思科医药集团股份有限公司 | 2022-07-29 | — | — | CN | disclosed |