Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | GAA | P10253 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | GLA | P06280 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.55 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | ESR1 | P03372 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.40 |
| ▸ | HTR3A | P46098 | 1/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | IKBKB | O14920 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30075088 | 0.89 | ALDH1A1 (0.55) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| SCHEMBL28228752 | 0.86 | ALDH1A1 (0.56) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| Thiourea SCHEMBL27997998 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| SCHEMBL222908 | 0.81 | NR4A1 (0.60) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| SCHEMBL27356901 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| Water SCHEMBL7769203 | 0.80 | NR4A1 (0.58) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| SCHEMBL8850857 | 0.80 | NR4A1 (0.58) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| SCHEMBL5352931 | 0.80 | ALDH1A1 (0.53) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| Acridine SCHEMBL29774329 | 0.80 | NR4A1 (0.58) | ALDH1A1KMT2AGAAKDM4EHPGD | |
| Acridine SCHEMBL31147690 | 0.80 | NR4A1 (0.58) | ALDH1A1KMT2AGAAKDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102231983-A | Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors | UNIV NORTH CAROLINA | 2011-11-02 | — | — | CN | claimed |
| CN-102231984-A | Hematopoietic protection against chemotherapeutic compounds using selective cyclin dependent kinase 4/6 inhibitors | UNIV NORTH CAROLINA | 2011-11-02 | — | — | CN | claimed |
| CN-103501789-A | Protection of renal tissue from ischemia by inhibition of the proliferative kinases CDK4 and CDK6 | UNIV NORTH CAROLINA | 2014-01-08 | — | — | CN | disclosed |
| CN-102458443-A | Cyclin-dependent kinase inhibitors and methods of use | UNIV NORTH CAROLINA | 2012-05-16 | — | — | CN | disclosed |
| CN-102231983-A | Hematopoietic protection against ionizing radiation using selective cyclin-dependent kinase 4/6 inhibitors | UNIV NORTH CAROLINA | 2011-11-02 | — | — | CN | disclosed |
| CN-102231984-A | Hematopoietic protection against chemotherapeutic compounds using selective cyclin dependent kinase 4/6 inhibitors | UNIV NORTH CAROLINA | 2011-11-02 | — | — | CN | disclosed |