Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 4/20 | 0.92 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.62 |
| ▸ | CCR1 | P32246 | 5/20 | 0.58 |
| ▸ | CCR8 | P51685 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.58 |
| ▸ | CCR5 | P51681 | 3/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.58 |
| ▸ | MMP2 | P08253 | 2/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.58 |
| ▸ | GMNN | O75496 | 1/20 | 0.58 |
| ▸ | TP53 | P04637 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | MMP9 | P14780 | 1/20 | 0.58 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL27811005 | 0.98 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL8313 | 0.96 | LMNA (1.00) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL6513577 | 0.96 | LMNA (1.00) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL4447950 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL722331 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL724138 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL4858817 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL1814141 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL10789328 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT | |
| SCHEMBL8728454 | 0.94 | LMNA (0.96) | LMNACYP3A4CCR1CCR8MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102274347-A | Anticancer composition and application thereof | — | 2011-12-14 | — | — | CN | claimed |
| CN-102274347-B | Anticancer composition | CHEN DI | 2013-11-06 | — | — | CN | disclosed |
| CN-102274347-A | Anticancer composition and application thereof | — | 2011-12-14 | — | — | CN | disclosed |