Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093587 | 0.81 | LMNA (0.61) | LMNAHPGDSMN1; SMN2NLRP3POLB | |
| SCHEMBL2093582 | 0.79 | LMNA (0.59) | LMNAHPGDSMN1; SMN2NLRP3POLB | |
| SCHEMBL21164704 | 0.77 | LMNA (0.56) | LMNAHPGDSMN1; SMN2NLRP3POLB | |
| SCHEMBL2092062 | 0.76 | LMNA (0.69) | LMNAHPGDNLRP3POLBMEN1 | |
| SCHEMBL12883186 | 0.74 | TSHR (0.77) | LMNAHPGDNLRP3POLBMEN1 | |
| SCHEMBL2092059 | 0.74 | LMNA (0.67) | LMNAHPGDNLRP3POLBMEN1 | |
| SCHEMBL3952909 | 0.73 | ALDH1A1 (0.68) | LMNAHPGDSMN1; SMN2POLBMEN1 | |
| SCHEMBL3899409 | 0.73 | LMNA (0.96) | LMNAHPGDNLRP3POLBMEN1 | |
| SCHEMBL11578854 | 0.73 | LMNA (0.70) | LMNAHPGDPOLBMEN1KMT2A | |
| SCHEMBL4214095 | 0.73 | LMNA (0.65) | LMNAHPGDNLRP3POLBMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114667286-A | Triazatricycles for the treatment of autoimmune diseases | 豪夫迈·罗氏有限公司 | 2022-06-24 | — | — | CN | disclosed |