Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 6/20 | 0.40 |
| ▸ | PRKD2 | Q9BZL6 | 5/20 | 0.40 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 10/20 | 0.39 |
| ▸ | WNT1 | P04628 | 8/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29635053 | 1.00 | PRKCZ (0.40) | PRKCZPRKD2BRD4ATAD2DYRK1A | |
| SCHEMBL28359184 | 0.90 | BRD4 (0.50) | PRKCZPRKD2BRD4ATAD2DYRK1A | |
| SCHEMBL29635095 | 0.90 | BRD4 (0.50) | PRKCZPRKD2BRD4ATAD2DYRK1A | |
| SCHEMBL28796471 | 0.82 | KIT (0.46) | BRD4PIM1 | |
| SCHEMBL29635086 | 0.80 | ABL1 (0.50) | ABL1 | |
| SCHEMBL28796403 | 0.80 | ABL1 (0.50) | ABL1 | |
| SCHEMBL29635084 | 0.78 | AURKA (0.43) | BRD4DYRK1AWNT1PIM1CHEK1 | |
| SCHEMBL28796397 | 0.78 | AURKA (0.43) | BRD4DYRK1AWNT1PIM1CHEK1 | |
| SCHEMBL28796391 | 0.76 | BRD4 (0.40) | BRD4DYRK1AWNT1PIM1CHEK1 | |
| SCHEMBL29635045 | 0.76 | BRD4 (0.40) | BRD4DYRK1AWNT1PIM1CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113248472-B | Anti-osteoporosis compound and derivative thereof, pharmaceutical composition, preparation method and application | 中国药科大学 | 2022-06-28 | — | — | CN | claimed |
| CN-113248472-A | Anti-osteoporosis compound and derivative thereof, pharmaceutical composition, preparation method and application | 中国药科大学 | 2021-08-13 | — | — | CN | claimed |
| CN-113248472-B | Anti-osteoporosis compound and derivative thereof, pharmaceutical composition, preparation method and application | 中国药科大学 | 2022-06-28 | — | — | CN | disclosed |
| CN-113248472-A | Anti-osteoporosis compound and derivative thereof, pharmaceutical composition, preparation method and application | 中国药科大学 | 2021-08-13 | — | — | CN | disclosed |