Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.33 |
| ▸ | SLC2A2 | P11168 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.32 |
| ▸ | PDE4A | P27815 | 1/20 | 0.32 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27882093 | 0.88 | RXRA (0.37) | RXRAGRIN1GRIN2BHDAC9SMN1; SMN2 | |
| SCHEMBL27865518 | 0.84 | HDAC9 (0.32) | HDAC9OPRL1HRH3 | |
| SCHEMBL1804220 | 0.82 | OPRL1 (0.33) | HDAC9TP53MAPTSMN1; SMN2OPRL1 | |
| SCHEMBL1807238 | 0.81 | HDAC9 (0.33) | HDAC9SMN1; SMN2HRH3 | |
| SCHEMBL1804749 | 0.79 | MAPT (0.45) | HDAC9TP53MAPTSMN1; SMN2HRH3 | |
| SCHEMBL27881813 | 0.76 | GRM5 (0.32) | RXRAGRIN1GRIN2BHDAC9 | |
| SCHEMBL27865519 | 0.73 | HDAC9 (0.34) | RXRAGRIN1GRIN2BHDAC9OPRL1 | |
| SCHEMBL1805973 | 0.71 | KDM4E (0.39) | HDAC9TP53MAPTSMN1; SMN2OPRL1 | |
| SCHEMBL27872051 | 0.68 | PDE10A (0.46) | SMN1; SMN2P2RX7PDE10ATDP1L3MBTL1 | |
| SCHEMBL1806926 | 0.67 | L3MBTL1 (0.41) | HDAC9TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102612520-A | Spiropiperidine compounds as orl-1 receptor antagonists | LILLY CO ELI | 2012-07-25 | — | — | CN | disclosed |