Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 7/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.51 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 5/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9547523 | 0.87 | PKM (0.71) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL11537146 | 0.87 | PKM (0.71) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL10537868 | 0.85 | PKM (0.69) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL27874519 | 0.84 | EPHX1 (0.61) | PKMRAB9ASMN1; SMN2EPHX1GAA | |
| SCHEMBL28207670 | 0.81 | PKM (0.68) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL19527789 | 0.81 | PKM (0.44) | PKMRAB9ALMNAALDH1A1KMT2A | |
| SCHEMBL11254288 | 0.79 | PKM (0.66) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL3483068 | 0.78 | PKM (0.60) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL18388053 | 0.78 | PKM (0.58) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 | |
| SCHEMBL11422598 | 0.78 | PKM (0.58) | PKMRAB9ASMN1; SMN2EPHX1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102471339-A | Pyrrolopyridine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | claimed |
| CN-102471339-A | Pyrrolopyridine inhibitors of kinases | ABBOTT LAB | 2012-05-23 | — | — | CN | disclosed |