Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | ATM | Q13315 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27887744 | 0.84 | CYP2A13 (0.43) | KDM4EKMT2AALDH1A1POLBSIRT2 | |
| SCHEMBL27993463 | 0.81 | CYP2A13 (0.43) | KDM4EKMT2AALDH1A1MEN1 | |
| SCHEMBL27871497 | 0.81 | CYP2A13 (0.43) | KDM4EKMT2AALDH1A1ATMMEN1 | |
| SCHEMBL27993464 | 0.80 | SIRT2 (0.41) | ALDH1A1NPSR1GAASIRT2SIRT1 | |
| SCHEMBL27887740 | 0.79 | SMN1; SMN2 (0.47) | KDM4EKMT2AALDH1A1MEN1POLB | |
| SCHEMBL27818451 | 0.78 | MEN1 (0.41) | KMT2AALDH1A1MEN1 | |
| SCHEMBL28120392 | 0.78 | MEN1 (0.41) | KMT2AALDH1A1MEN1 | |
| SCHEMBL27887733 | 0.78 | HIF1A (0.42) | KDM4EALDH1A1 | |
| SCHEMBL27871495 | 0.78 | ACHE (0.45) | KDM4EKMT2AALDH1A1MEN1POLB | |
| SCHEMBL27871494 | 0.77 | MAPT (0.46) | KDM4EKMT2AALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102675240-B | 4-substitute-2-hydroxy morpholine-3-ketone and preparation method thereof | ZHEJIANG HISUN PHARM CO LTD | 2015-01-14 | — | — | CN | disclosed |
| CN-102675240-A | 4-substitute-2-hydroxy morpholine-3-one and preparation method thereof | ZHEJIANG HISUN PHARM CO LTD | 2012-09-19 | — | — | CN | disclosed |