Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 5/20 | 0.60 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.55 |
| ▸ | PBK | Q96KB5 | 5/20 | 0.47 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | DPP4 | P27487 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | FAP | Q12884 | 1/20 | 0.43 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.43 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13325381 | 0.85 | NAMPT (0.63) | NAMPTSMYD3SMN1; SMN2KDM4E | |
| SCHEMBL5094284 | 0.85 | NAMPT (0.63) | NAMPTSMYD3SMN1; SMN2KDM4E | |
| SCHEMBL13325386 | 0.85 | NAMPT (0.63) | NAMPTSMYD3SMN1; SMN2KDM4E | |
| SCHEMBL14720114 | 0.83 | SMYD3 (0.58) | NAMPTSMYD3KDM4E | |
| SCHEMBL17888454 | 0.83 | SMYD3 (0.58) | NAMPTSMYD3CYP2D6 | |
| SCHEMBL8255991 | 0.83 | SMYD3 (0.58) | NAMPTSMYD3 | |
| SCHEMBL21900928 | 0.81 | NAMPT (0.59) | NAMPTSMYD3 | |
| SCHEMBL17886756 | 0.81 | SMYD3 (0.56) | NAMPTSMYD3SMN1; SMN2 | |
| SCHEMBL8257484 | 0.80 | SMN1; SMN2 (0.55) | NAMPTSMYD3SMN1; SMN2 | |
| SCHEMBL8257974 | 0.78 | SMYD3 (0.53) | NAMPTSMYD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102924445-A | PIM kinase inhibitor, preparation method thereof, and application thereof in pharmacy | SHANGHAI JIKAI MEDICAL TECHNOLOGY CO LTD | 2013-02-13 | — | — | CN | disclosed |