SCHEMBL28801075

SCHEMBL28801075

O=C(Br)c1cncc(Br)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
POLB P06746 2/20 0.69
HCAR2 Q8TDS4 1/20 0.69
KDM4E B2RXH2 1/20 0.60
HTT P42858 4/20 0.58
ALOX15 P16050 1/20 0.58
SMN1; SMN2 Q16637 3/20 0.56
MAPT P10636 1/20 0.56
RAB9A P51151 2/20 0.55
ROCK2 O75116 1/20 0.51
ALDH1A1 P00352 1/20 0.51
GAA P10253 1/20 0.51
ALOX12 P18054 1/20 0.51
ROCK1 Q13464 1/20 0.51
MEN1 O00255 1/20 0.51
KMT2A Q03164 1/20 0.51
PKM P14618 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
EGFR P00533 2/20 0.47
SMYD3 Q9H7B4 1/20 0.46
CASP3 P42574 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21332094 0.85 HCAR2 (0.48) POLBHCAR2KDM4EHTTALOX15
SCHEMBL22569116 0.84 HTT (0.78) POLBHCAR2KDM4EHTTALOX15
SCHEMBL112388 0.82 HCAR2 (1.00) POLBHCAR2KDM4EHTTALOX15
SCHEMBL29603529 0.82 HCAR2 (1.00) POLBHCAR2KDM4EHTTALOX15
SCHEMBL10461109 0.80 HCAR2 (0.96) POLBHCAR2KDM4EHTTALOX15
SCHEMBL431067 0.80 POLB (0.67) POLBHCAR2KDM4EHTTALOX15
SCHEMBL578591 0.80 POLB (0.67) POLBHCAR2KDM4EHTTALOX15
SCHEMBL31137907 0.80 POLB (0.67) POLBHCAR2KDM4EHTTALOX15
SCHEMBL10500665 0.80 HCAR2 (0.96) POLBHCAR2KDM4EHTTALOX15
Hydrochloric Acid SCHEMBL6525205 0.80 HCAR2 (0.96) POLBHCAR2KDM4EHTTALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102718761-A Preparation method for nicergoline ZHUHAI RUNDU PHARMACEUTICAL CO LTD 2012-10-10 CN claimed
CN-102718761-A Preparation method for nicergoline ZHUHAI RUNDU PHARMACEUTICAL CO LTD 2012-10-10 CN disclosed