Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 5/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 12/20 | 0.40 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.38 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17827128 | 0.83 | JAK3 (0.39) | JAK1JAK3JAK2MAPK1RIPK1 | |
| SCHEMBL2319051 | 0.81 | JAK3 (0.51) | JAK1JAK3JAK2MAPK1RIPK1 | |
| SCHEMBL22981473 | 0.77 | PAX8 (0.37) | JAK1JAK3JAK2PAX8 | |
| SCHEMBL27893041 | 0.75 | SYK (0.39) | JAK1JAK3JAK2MAPK1PAX8 | |
| SCHEMBL16249709 | 0.75 | JAK1 (0.49) | JAK1JAK3JAK2 | |
| SCHEMBL23616433 | 0.74 | JAK3 (0.51) | JAK1JAK3JAK2MAPK1 | |
| SCHEMBL2318269 | 0.72 | MEN1 (0.46) | JAK1JAK3JAK2MAPK1RIPK1 | |
| SCHEMBL2376996 | 0.72 | JAK3 (0.70) | JAK1JAK3JAK2 | |
| SCHEMBL12389613 | 0.71 | JAK1 (0.46) | JAK1JAK3JAK2MAPK1 | |
| SCHEMBL28334344 | 0.70 | MAPK1 (0.48) | JAK1JAK3JAK2MAPK1RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102711470-A | Novel tricyclic compounds | ABBOTT LAB | 2012-10-03 | — | — | CN | disclosed |