Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | LIG1 | P18858 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10631908 | 0.85 | BRD4 (0.61) | POLBLIG1ALDH1A1GAAKDM4E | |
| SCHEMBL30428722 | 0.85 | BRD4 (0.61) | POLBLIG1ALDH1A1GAAKDM4E | |
| SCHEMBL10745183 | 0.83 | POLB (0.55) | POLBLIG1ALDH1A1GAAKDM4E | |
| SCHEMBL9790155 | 0.81 | GAA (0.69) | POLBALDH1A1GAAKDM4ENPC1 | |
| SCHEMBL20037048 | 0.81 | POLB (0.59) | POLBLIG1ALDH1A1GAANPC1 | |
| SCHEMBL18415551 | 0.79 | POLB (0.62) | POLBALDH1A1GAAKDM4ENPC1 | |
| SCHEMBL14019905 | 0.79 | GAA (0.50) | POLBLIG1ALDH1A1GAAKDM4E | |
| SCHEMBL11781967 | 0.78 | ALDH1A1 (0.61) | POLBLIG1ALDH1A1GAASMN1; SMN2 | |
| SCHEMBL7303695 | 0.76 | NPC1 (0.54) | POLBLIG1ALDH1A1GAANPC1 | |
| SCHEMBL13345411 | 0.76 | POLB (0.44) | POLBLIG1ALDH1A1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010043866-A2 | HISTONE LYSINE DEMETHYLASE INHIBITORS | ISIS INNOVATION LIMITED (GB) | 2010-04-22 | — | — | WO | disclosed |