Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dl-Phenylalanine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPI | P09923 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | XIAP | P98170 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | CTSC | P53634 | 2/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.38 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.38 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.37 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.37 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dl-Phenylalanine SCHEMBL25411672 | 0.97 | ALPI (0.41) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL10379632 | 0.96 | ANPEP (0.43) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL27660741 | 0.94 | SLC7A5 (0.49) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL9903540 | 0.94 | ALPI (0.38) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL3653220 | 0.92 | SLC7A5 (0.51) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL294308 | 0.91 | ALPI (0.36) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL29176066 | 0.90 | REN (0.44) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL10379627 | 0.90 | ANPEP (0.48) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Dl-Phenylalanine SCHEMBL12483321 | 0.90 | SLC7A5 (0.45) | ALPIPKMPTGS1XIAPSLC7A5 | |
| Phenylalanine SCHEMBL12483330 | 0.90 | SLC7A5 (0.45) | ALPIPKMPTGS1XIAPSLC7A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853848-B | Polypeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114853848-A | Polypeptide compound and application thereof in preparing medicament for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-08-05 | — | — | CN | disclosed |