Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL27660744 | 0.94 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL1543511 | 0.94 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL5583260 | 0.93 | CYP3A4 (0.31) | — | |
| Histidine SCHEMBL28519332 | 0.93 | MEN1 (0.31) | — | |
| Histidine SCHEMBL28528367 | 0.91 | — | — | |
| Histidine SCHEMBL19809592 | 0.91 | — | — | |
| Histidine SCHEMBL27660746 | 0.89 | SLC7A5 (0.31) | — | |
| Histidine SCHEMBL16444321 | 0.88 | CYP3A4 (0.32) | — | |
| Histidine SCHEMBL2586200 | 0.87 | SLC7A5 (0.35) | — | |
| D-Histidine SCHEMBL11606906 | 0.87 | SLC7A5 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114853848-B | Polypeptide compound and application thereof in preparation of medicines for treating liver fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2023-10-24 | — | — | CN | disclosed |
| CN-114853848-A | Polypeptide compound and application thereof in preparing medicament for treating hepatic fibrosis diseases | 陕西慧康生物科技有限责任公司 | 2022-08-05 | — | — | CN | disclosed |