Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Histidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Histidine SCHEMBL28801818 | 0.93 | — | — | |
| Histidine SCHEMBL5064964 | 0.90 | MEN1 (0.36) | MEN1KMT2A | |
| Histidine SCHEMBL6554544 | 0.90 | MEN1 (0.30) | MEN1KMT2A | |
| Histidine SCHEMBL28219638 | 0.88 | BHMT (0.32) | — | |
| Histidine SCHEMBL1543511 | 0.88 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL27660744 | 0.88 | CYP3A4 (0.30) | — | |
| Histidine SCHEMBL5583260 | 0.87 | CYP3A4 (0.31) | — | |
| Histidine SCHEMBL7756453 | 0.86 | CALCR (0.32) | — | |
| Histidine SCHEMBL7758642 | 0.85 | CALCR (0.34) | — | |
| Histidine SCHEMBL28528367 | 0.85 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108101960-B | Polypeptide molecule with ACE inhibitory activity and anti-tumor effect and preparation method thereof | 湖北工业大学 | 2020-12-29 | — | — | CN | claimed |
| CN-108101960-B | Polypeptide molecule with ACE inhibitory activity and anti-tumor effect and preparation method thereof | 湖北工业大学 | 2020-12-29 | — | — | CN | disclosed |
| CN-108101960-B | Polypeptide molecule with ACE inhibitory activity and anti-tumor effect and preparation method thereof | 湖北工业大学 | 2020-12-29 | — | — | CN | disclosed |