Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.44 |
| ▸ | JAK3 | P52333 | 13/20 | 0.44 |
| ▸ | JAK1 | P23458 | 8/20 | 0.42 |
| ▸ | TYK2 | P29597 | 7/20 | 0.42 |
| ▸ | FLT3 | P36888 | 6/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27917227 | 0.91 | JAK2 (0.43) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL28805482 | 0.85 | JAK2 (0.41) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL28805476 | 0.84 | JAK2 (0.40) | JAK2JAK3TYK2FLT3HDAC1 | |
| SCHEMBL27917289 | 0.80 | JAK2 (0.44) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL4561892 | 0.80 | JAK2 (0.51) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL27967482 | 0.75 | JAK1 (0.40) | JAK2JAK3JAK1TYK2 | |
| SCHEMBL4561800 | 0.75 | JAK2 (0.43) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL4562555 | 0.74 | JAK2 (0.59) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL4562646 | 0.71 | JAK2 (0.48) | JAK2JAK3JAK1TYK2FLT3 | |
| SCHEMBL28807355 | 0.71 | JAK2 (0.43) | JAK2JAK3JAK1TYK2FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | claimed |
| CN-103298794-A | Pyridine compounds and aza analogues thereof as TYK2 inhibitors | CELLZOME LTD | 2013-09-11 | — | — | CN | disclosed |